Skip to main contentSkip to main content
You have permission to edit this article.
Edit

Mepolizumab Cuts Exacerbations in Children With Severe Asthma

  • Updated
  • 0
Mepolizumab Cuts Exacerbations in Children With Severe Asthma

MONDAY, Aug. 15, 2022 (HealthDay News) -- Asthma exacerbations are reduced for children and adolescents with exacerbation-prone eosinophilic asthma who are living in socioeconomically disadvantaged urban neighborhoods and receive mepolizumab therapy, according to a study published in the Aug. 13 issue of The Lancet.

Daniel J. Jackson, M.D., from the University of Wisconsin School of Medicine and Public Health in Madison, and colleagues conducted a randomized trial at nine urban medical centers in the United States involving children and adolescents aged 6 to 17 years who lived in socioeconomically disadvantaged neighborhoods and had exacerbation-prone asthma and blood eosinophils of at least 150 cells/µL. A total of 290 participants were randomly assigned to either mepolizumab or placebo injections once every four weeks plus guideline-based care for 52 weeks (146 and 144 patients, respectively).

The researchers found that within the 52-week study period, the mean number of asthma exacerbations was 0.96 and 1.30 with mepolizumab and placebo, respectively (rate ratio, 0.73). Treatment-emergent adverse events occurred in 29 and 11 percent of participants in the mepolizumab and placebo groups, respectively. There were no deaths attributed to mepolizumab.

"In urban children and adolescents with exacerbation-prone eosinophilic asthma, adjunctive therapy with mepolizumab reduced asthma exacerbations, but did not affect other asthma outcomes," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including GlaxoSmithKline, which manufactures mepolizumab and partially funded the study.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

0 Comments

Originally published on consumer.healthday.com, part of the TownNews Content Exchange.

* I understand and agree that registration on or use of this site constitutes agreement to its user agreement and privacy policy.

Related to this story

Most Popular

In an alarming assessment, U.N. Secretary-General Antonio Guterres told world leaders Tuesday that nations are “gridlocked in colossal global dysfunction” and aren’t ready or willing to tackle the major challenges that threaten the future of humanity and the fate of the planet. Speaking at the opening of the General Assembly’s annual top-level meeting, the U.N. chief pointed to the war in Ukraine, multiplying conflicts around the world, the climate emergency, the dire financial situation of developing countries, and recent reversals of progress on such U.N. goals as ending extreme poverty and providing quality education for all children.

The Republican nominee for U.S. Senate in Pennsylvania, Dr. Mehmet Oz, has released his health records as he maneuvers to keep questions about Democratic rival John Fetterman’s recovery from a stroke front and center. Dr. Rebecca Kurth wrote in a letter that she found the heart surgeon-turned-TV celebrity to be in “excellent health” in an annual checkup Thursday. The release of the doctor’s note and health records comes as Oz has increasingly made Fetterman’s fitness to serve a central theme in his campaign and as Oz is trying to close a gap in polls. Fetterman maintains that doctors expect him to make a full recovery.

The way President Joe Biden sees it, the overturning of Roe vs. Wade by the Supreme Court wasn't just about whether a woman has the right to obtain an abortion. “It’s about freedom,” Biden said this past week while in New York. Vice President Kamala Harris tells voters that “extremist, so-called leaders trumpet the rhetoric of freedom while they take away freedoms." That deliberate echo of “freedom” from Biden, Harris and other top White House officials shows how Democrats at the highest ranks are increasingly co-opting traditionally conservative rhetoric in a blunt appeal to a broad swath of the electorate this fall.

After the pomp and pageantry of a grand state funeral, Queen Elizabeth II has been laid to rest with her husband and parents in an intimate ceremony at Windsor away from media cameras. King Charles III and senior royal family members attended the private interment ceremony late Monday at St. George’s Chapel. It's a gothic church on the grounds of Windsor Castle that has had royal weddings, christenings and burials since the 15th century. Officials said the queen was interred with Prince Philip’s remains at the King George VI memorial chapel, an annex within St. George’s. Elizabeth II’s parents, King George VI and Queen Elizabeth, were also interred there, along with the ashes of Princess Margaret, the late monarch’s younger sister.

Get up-to-the-minute news sent straight to your device.

Topics

Breaking News

Sports Breaking News

News Alert