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Colts vs. Broncos: FrontPageBets breaks down this Thursday night NFL matchup, odds and prediction

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Indianapolis Colts tight end Mo Alie-Cox (81) caught two Matt Ryan touchdown passes in the Colts' Week 4 win over Tennessee.

The Monday Night Football matchup between AFC West rivals Las Vegas and Kansas City highlights this week's slate of NFL games as we're a quarter of the way through the 2022 season.

A lot more was expected out of the Indianapolis Colts and Denver Broncos coming into the 2022 season than what both teams have shown through four weeks.

Both teams got steady, veteran quarterbacks in the offseason and had high hopes those signal-callers would give them the pieces they needed to make a postseason run.

Through the first month of play, both teams and quarterbacks – Matt Ryan for the Colts (1-2-1) and Russell Wilson for the Broncos (2-2) – have underwhelmed.

Thursday night, they face off in a prime-time matchup that could help jump-start their seasons.

FrontPageBets takes a look at three best bets for this AFC showdown, as well as who will win the game.

(All odds courtesy of DraftKings and are subject to change)

Colts QB Matt Ryan over 1.5 touchdown passes (+120)

Ryan has thrown two touchdown passes in each of his last two games. Considering he started the season with one touchdown pass in a Week 1 tie against the Houston Texans and then threw three interceptions and zero touchdowns in a loss to the Jacksonville Jaguars in Week 2, you could say Ryan is finding his stride.

After coming over from the Atlanta Falcons in the offseason, Ryan has led the Colts to back-to-back victories, including a big win against the Kansas City Chiefs in Week 3. He then threw for a season-high 356 yards and two scores against the Tennessee Titans this past Sunday.

Colts WR Michael Pittman Jr. over 5.5 receptions (+100)

As Ryan continues to steady himself with his new team, Indianapolis wide receiver Michael Pittman Jr. will certainly be a benefactor.

Although he missed Week 2 with injury, Pittman is averaging 9.3 targets and 6.6 catches per game, boosted by a big nine-reception, 121-yard and one-touchdown Week 1 performance.

The Broncos defense is 14th in the league against the pass. Ryan should look to get the ball to Pittman early and often.

Under 43.5 point total (-115)

Both Indianapolis and Denver are a combined 1-for-7 in over point totals this season, with only the Broncos hitting the over in Week 4 against the Raiders.

In prime-time games this season (Thursday night, Sunday night and Monday night), teams are 9-3 for the under.

In this week's FPBcast, Gerry Ahern and Mike Szvetitz also pick their matchups of the week in NFL and college football.

Indianapolis Colts (1-2-1) at Denver Broncos (2-2)

  • When: Thursday, 8:15p.m.; PRIME
  • Spread: Broncos -3.5 (-105); Colts +3.5 (-115)
  • Money line: Broncos -180; Colts +155
  • Over/Under: 43.5 (-110)
  • The pick: Colts, 21-20

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Mike Szvetitz is the General Manager and Content Director for Szvetitz is a 22-year veteran reporter and editor, including serving 17 years as a sports editor in Florida, Alabama and Virginia, covering everything from preps to pros. His "View From The Lazy Boy" column won multiple state and national awards. He can be reached at

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FrontPageBets takes a look at the top wagers to watch, starting off with the AFC title game rematch between the Kansas City Chiefs and the Cincinnati Bengals.

FrontPageBets' Mike Szvetitz knows it's not how you start, but how you finish. And sometimes you just got to go with your gut to get there.

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